say, you defined your toggle button bar as below
<mx:ToggleButtonBar id="tbbModule" itemClick="tbbModule_Click(event)">
<mx:Array>
<mx:String>Home</mx:String>
<mx:String>Module 1</mx:String>
<mx:String>Module 2</mx:String>
</mx:Array>
</mx:ToggleButtonBar>
If you want to disable the first button, then
mx.controls.Button(tbbModule.getChildAt(0)).enabled =false;